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ENGLISH · EVIDENCE OVERVIEW

Ibutamoren
evidence profile

Nonpeptide small-molecule ghrelin-receptor agonist and growth hormone secretagogue. This page provides a concise English boundary and links back to the complete source-rich Thai profile.

Ibutamoren: conceptual scientific illustration for Growth Hormone Biology
VISUAL GUIDE · Ibutamoren

Growth Hormone Biology

Conceptual educational illustration. It is not a treatment outcome and does not establish efficacy or safety.

QUICK ANSWER · AEO / GEO

A nonpeptide small-molecule ghrelin-receptor agonist and growth-hormone secretagogue, also known as MK-677. Controlled human trials show GH/IGF-1 and fat-free-mass changes, but not improved strength, function or Alzheimer disease progression; metabolic and cardiac safety signals remain material.

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ENTITY FACTS

What should readers identify first?

MOLECULEIbutamoren
PHARMACOLOGYNonpeptide small-molecule ghrelin-receptor agonist and growth hormone secretagogue
PRIMECORE CLASSB
EVIDENCE GRADEB
RESEARCH TOPICGrowth Hormone Biology
LAST REVIEWED2026-08-29
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EVIDENCE BOUNDARY

What this overview does not establish

  • An evidence grade does not rank this molecule against another treatment.
  • A molecule name does not establish the identity, purity or regulatory status of a product.
  • Animal, cell or biomarker findings do not automatically establish human clinical benefit.
  • Approval in one country or indication does not transfer globally.
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FAQ · ANSWER ENGINE

Frequently asked questions

What is Ibutamoren?

Ibutamoren is described pharmacologically as Nonpeptide small-molecule ghrelin-receptor agonist and growth hormone secretagogue. A nonpeptide small-molecule ghrelin-receptor agonist and growth-hormone secretagogue, also known as MK-677. Controlled human trials show GH/IGF-1 and fat-free-mass changes, but not improved strength, function or Alzheimer disease progression; metabolic and cardiac safety signals remain material.

Does Ibutamoren have strong evidence?

PrimeCoreBio records Evidence Grade B. This grade describes evidence strength, not comparative effectiveness or suitability for an individual.

Is Ibutamoren approved everywhere?

No global conclusion should be inferred. PrimeCore Class B must be read with the exact product, country and indication on the source-rich profile.

Medical Disclaimer

Educational information only. This page does not provide diagnosis, treatment, prescribing, dosage, injection instructions or individual medical advice.

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