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ENGLISH · EVIDENCE OVERVIEW

Duloxetine
evidence profile

Serotonin and norepinephrine reuptake inhibitor (SNRI). This is a concise English overview, not a full translation. Read the evidence boundaries and original sources below; the detailed study and risk discussion remains available in Thai.

What do Class, Grade and Risk mean?

Duloxetine: conceptual scientific illustration for Sexual Medicine Pharmacology
VISUAL GUIDE · Duloxetine

Sexual Medicine Pharmacology

Category-level conceptual illustration, not a map of this molecule's receptor targets. It is not a treatment outcome and does not establish efficacy or safety.

QUICK ANSWER · AEO / GEO

An SNRI with product-specific psychiatric and pain indications; two premature-ejaculation RCTs are discussed by EAU, but longer-term evidence is still requested before widespread recommendation.

01

ENTITY FACTS

What should readers identify first?

MOLECULEDuloxetine
PHARMACOLOGYSerotonin and norepinephrine reuptake inhibitor (SNRI)
PRIMECORE CLASSA
EVIDENCE GRADEB
RESEARCH TOPICSexual Medicine Pharmacology
LAST REVIEWED2026-08-29

What remains unknown?

English translation is not yet verified for 3 excerpt(s). This is a language gap, not an absence of risks or uncertainty.

Read original excerpts (Thai / mixed language)
  • งานทดลอง PE สองงานไม่ทำให้ duloxetine เป็นยาที่อนุมัติสำหรับ PE และไม่เท่ากับคำแนะนำให้ใช้อย่างแพร่หลาย
  • Duloxetine เป็น SNRI ไม่ใช่ SSRI และไม่ควรถ่ายโอนหลักฐานหรือความเสี่ยงจาก paroxetine, sertraline, fluoxetine, citalopram หรือ fluvoxamine มาใช้แทน
  • ผลต่อการหลั่งไม่ใช่หลักฐานรักษาภาวะหย่อนสมรรถภาพทางเพศ เพิ่มความต้องการ หรือเพิ่มความพึงพอใจในทุกคน

What limits these conclusions?

Insufficient data in the current dataset

This overview does not replace the detailed adverse-event and product-specific risk discussion in the complete Thai profile or the original sources.

02

EVIDENCE BOUNDARY

What this overview does not establish

  • An evidence grade does not rank this molecule against another treatment.
  • A molecule name does not establish the identity, purity or regulatory status of a product.
  • Animal, cell or biomarker findings do not automatically establish human clinical benefit.
  • Approval in one country or indication does not transfer globally.

Where can I check the evidence?

Original sources from the same evidence record used by Compare. Read each source's population, methods, limitations and date; a citation is not product endorsement.

  1. DailyMed — current duloxetine delayed-release label
  2. U.S. FDA — Cymbalta prescribing information
  3. Thai FDA — reviewed CYMBALTA registration
  4. EAU — Disorders of ejaculation
  5. EAU — Sexual and Reproductive Health methodology
03

FAQ · ANSWER ENGINE

Frequently asked questions

What is Duloxetine?

Duloxetine is described pharmacologically as Serotonin and norepinephrine reuptake inhibitor (SNRI). An SNRI with product-specific psychiatric and pain indications; two premature-ejaculation RCTs are discussed by EAU, but longer-term evidence is still requested before widespread recommendation.

Does Duloxetine have strong evidence?

PrimeCoreBio records Evidence Grade B. This grade describes evidence strength, not comparative effectiveness or suitability for an individual.

Is Duloxetine approved everywhere?

No global conclusion should be inferred. PrimeCore Class A must be read with the exact product, country and indication on the source-rich profile.

Medical Disclaimer

Educational information only. This page does not provide diagnosis, treatment, prescribing, dosage, injection instructions or individual medical advice.

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