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ENGLISH · EVIDENCE OVERVIEW

Clomipramine
evidence profile

Tricyclic antidepressant (TCA) / serotonin and norepinephrine reuptake inhibitor. This is a concise English overview, not a full translation. Read the evidence boundaries and original sources below; the detailed study and risk discussion remains available in Thai.

What do Class, Grade and Risk mean?

Clomipramine: conceptual scientific illustration for Sexual Medicine Pharmacology
VISUAL GUIDE · Clomipramine

Sexual Medicine Pharmacology

Category-level conceptual illustration, not a map of this molecule's receptor targets. It is not a treatment outcome and does not establish efficacy or safety.

QUICK ANSWER · AEO / GEO

A tricyclic antidepressant approved for OCD in the reviewed U.S. label; premature-ejaculation evidence remains off-label and its cardiac, seizure, anticholinergic and interaction risks differ materially from SSRIs.

01

ENTITY FACTS

What should readers identify first?

MOLECULEClomipramine
PHARMACOLOGYTricyclic antidepressant (TCA) / serotonin and norepinephrine reuptake inhibitor
PRIMECORE CLASSA
EVIDENCE GRADEA
RESEARCH TOPICSexual Medicine Pharmacology
LAST REVIEWED2026-08-29

What remains unknown?

English translation is not yet verified for 3 excerpt(s). This is a language gap, not an absence of risks or uncertainty.

Read original excerpts (Thai / mixed language)
  • หลักฐาน PE ไม่เปลี่ยน clomipramine ให้เป็นยาที่อนุมัติสำหรับ PE โดยอัตโนมัติ
  • ผลต่อการหลั่งไม่ใช่หลักฐานรักษาภาวะหย่อนสมรรถภาพทางเพศ เพิ่มความต้องการ หรือเพิ่มความพึงพอใจในทุกคน
  • Anafranil, clomipramine generic และผลิตภัณฑ์ต่างประเทศมีฉลาก formulation และสถานะกำกับดูแลต่างกัน ไม่ควรใช้ชื่อแทนกันโดยไม่ตรวจผลิตภัณฑ์

What limits these conclusions?

Insufficient data in the current dataset

This overview does not replace the detailed adverse-event and product-specific risk discussion in the complete Thai profile or the original sources.

02

EVIDENCE BOUNDARY

What this overview does not establish

  • An evidence grade does not rank this molecule against another treatment.
  • A molecule name does not establish the identity, purity or regulatory status of a product.
  • Animal, cell or biomarker findings do not automatically establish human clinical benefit.
  • Approval in one country or indication does not transfer globally.

Where can I check the evidence?

Original sources from the same evidence record used by Compare. Read each source's population, methods, limitations and date; a citation is not product endorsement.

  1. U.S. FDA — Anafranil prescribing information
  2. DailyMed — current clomipramine label
  3. EMA — clomipramine PSUSA
  4. EMA — nationally authorised clomipramine products
  5. EAU — Disorders of ejaculation
  6. Thai FDA — medicine search
  7. EAU — Sexual and Reproductive Health methodology
03

FAQ · ANSWER ENGINE

Frequently asked questions

What is Clomipramine?

Clomipramine is described pharmacologically as Tricyclic antidepressant (TCA) / serotonin and norepinephrine reuptake inhibitor. A tricyclic antidepressant approved for OCD in the reviewed U.S. label; premature-ejaculation evidence remains off-label and its cardiac, seizure, anticholinergic and interaction risks differ materially from SSRIs.

Does Clomipramine have strong evidence?

PrimeCoreBio records Evidence Grade A. This grade describes evidence strength, not comparative effectiveness or suitability for an individual.

Is Clomipramine approved everywhere?

No global conclusion should be inferred. PrimeCore Class A must be read with the exact product, country and indication on the source-rich profile.

Medical Disclaimer

Educational information only. This page does not provide diagnosis, treatment, prescribing, dosage, injection instructions or individual medical advice.

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