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Evidence boundaries, not cross-trial treatment outcomes
Molecule	SR9009	SLU-PP-332	AICAR (Acadesine)
Research Topic	Mitochondrial / Metabolic Research	Mitochondrial / Metabolic Research	Mitochondrial / Metabolic Research
Pharmacology	Experimental small molecule / REV-ERB-related research	Experimental small-molecule ERRα/β/γ agonist; not a peptide	Investigational purine nucleoside analogue / adenosine-regulating agent; not a peptide
PrimeCore Class	Class CExperimental / limited evidence	Class CExperimental / limited evidence	Class BInvestigational
Evidence Grade	Grade EPreclinical evidence	Grade EPreclinical evidence	Grade BStrong controlled human evidence
Evidence boundary	SR9009 is an experimental small molecule, not a SARM or peptide. Genetic studies demonstrate REV-ERB-independent effects, limiting target-specific claims. Cell and mouse results do not establish human fat-loss, endurance or cardiac benefit, and human safety remains unverified.	An experimental ERR agonist with preclinical-only evidence; animal exercise-mimetic findings do not establish human benefit.	A nucleoside analogue and AMPK-related research compound, not a peptide; clinical and anti-doping contexts must be separated.
Unknowns	Insufficient data in the current dataset	human pharmacokinetics, bioavailability and target engagement safe exposure range and short- or long-term adverse effects in humans whether mouse endurance and metabolic findings translate to people comparability between published research material and products offered online current product-specific status in Thailand, the United States, European Union and United Kingdom case-specific anti-doping classification and analytical thresholds	long-term safety outside short perioperative research settings human risk-benefit for weight, metabolic or performance claims effects of repeated exposure on purine, glucose and lipid metabolism comparability of research-grade AICAR, acadesine formulations and online products current product-specific marketing-authorisation status in Thailand, the EU and UK current US compounding-list status under a substance-specific FDA review
Limitations	English translation is not yet verified for 1 excerpt(s). This is a language gap, not an absence of risks or uncertainty. Read original excerpts (Thai / mixed language) SR9009 ≠ SARM; mouse metabolism ≠ human exercise benefit; เป้าหมายที่คาดไม่เท่ากับกลไกที่พิสูจน์ครบ	The core efficacy literature consists of cell and mouse studies from a limited research lineage. Human-derived cell work does not establish exposure, efficacy or safety in a person. No verified clinical administration dataset means an evidence grade above E is not justified. Later work on SLU-PP-915 is about a different molecule and cannot be transferred to SLU-PP-332.	Strong controlled human evidence exists only in a narrow CABG setting and culminated in a negative confirmatory trial. Older meta-analytic and post-hoc signals must be interpreted in light of RED-CABG. Popular performance claims are based mainly on mouse work. Mechanistic studies also show that AICAR is not selective for AMPK, limiting simple pathway-based conclusions.
Sources	Target-specificity study · PMID 31127047 Cardiac knockout model · PMID 35911512	https://pertento.fda.moph.go.th/FDA_SEARCH_DRUG/SEARCH_DRUG/FRM_SEARCH_DRUG.aspx https://www.accessdata.fda.gov/scripts/cder/daf/ https://clinicaltrials.gov/search?term=%22SLU-PP-332%22 https://www.ema.europa.eu/en/medicines/download-medicine-data https://pubmed.ncbi.nlm.nih.gov/36988910/ https://pubmed.ncbi.nlm.nih.gov/37739806/ https://pubmed.ncbi.nlm.nih.gov/40692696/ https://pubmed.ncbi.nlm.nih.gov/41688415/ https://pubmed.ncbi.nlm.nih.gov/41421047/ https://www.wada-ama.org/en/resources/world-anti-doping-program/prohibited-list https://www.wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf https://products.mhra.gov.uk/	https://precision.fda.gov/uniisearch/srs/unii/53ief47846 https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=203105 https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=341011 https://www.fda.gov/media/94155/download https://www.fda.gov/media/94164/download https://clinicaltrials.gov/study/NCT00872001 https://pubmed.ncbi.nlm.nih.gov/7818622/ https://pubmed.ncbi.nlm.nih.gov/7574044/ https://pubmed.ncbi.nlm.nih.gov/9002496/ https://pubmed.ncbi.nlm.nih.gov/22782417/ https://pubmed.ncbi.nlm.nih.gov/7744080/ https://pubmed.ncbi.nlm.nih.gov/18674809/ https://pubmed.ncbi.nlm.nih.gov/27103440/ https://pubmed.ncbi.nlm.nih.gov/34064363/ https://www.wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf https://products.mhra.gov.uk/ https://www.ema.europa.eu/en/medicines/download-medicine-data https://pertento.fda.moph.go.th/FDA_SEARCH_DRUG/SEARCH_DRUG/FRM_SEARCH_DRUG.aspx
Read more	Read English overview Complete evidence profile (Thai)	Read English overview Complete evidence profile (Thai)	Read English overview Complete evidence profile (Thai)

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Missing fields mean information is unavailable in the current structured dataset, not that a molecule has no risks or uncertainties. English translations retain the original evidence boundaries. Where translation is not yet verified, the original Thai excerpts remain available under an explicit label. Sources retain their original language.

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