SIDE-BY-SIDE EVIDENCE

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Select 2–3 profiles from the English Library. Class and grade describe evidence and regulatory context, not comparative effectiveness or suitability for an individual.

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SIDE-BY-SIDE EVIDENCE VIEW

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Evidence comparison · not a treatment ranking

Evidence boundaries, not cross-trial treatment outcomes
Molecule	Levothyroxine / T4	Liothyronine sodium / T3	Prednisone
Research Topic	Clinical / Endocrine Pharmacology	Clinical / Endocrine Pharmacology	Clinical / Endocrine Pharmacology
Pharmacology	Prescription thyroid hormone (synthetic T4)	Prescription thyroid hormone (synthetic T3)	Systemic glucocorticoid prodrug medicine
PrimeCore Class	Class AApproved in a bounded context	Class AApproved in a bounded context	Class AApproved in a bounded context
Evidence Grade	Grade AStrong regulatory + clinical evidence	Grade AStrong regulatory + clinical evidence	Grade AStrong regulatory + clinical evidence
Evidence boundary	Levothyroxine / T4 is classified here as Prescription thyroid hormone (synthetic T4). Strong clinical and regulatory evidence applies to hypothyroidism and other labelled contexts, not performance or non-deficient weight loss. FDA-authorised prescription products exist; the catalogue shorthand T4 does not establish manufacturer, potency or authorisation. A catalogue name does not establish identity, formulation, quality or authorisation, and this page provides no dosage, mixing, injection or purchasing instructions.	Liothyronine sodium / T3 is classified here as Prescription thyroid hormone (synthetic T3). Current labels support defined thyroid indications and carry a boxed warning against use for obesity or weight loss. FDA-authorised prescription labels exist for defined thyroid indications; WADA status and TUE requirements must be checked for an athlete's exact context. A catalogue name does not establish identity, formulation, quality or authorisation, and this page provides no dosage, mixing, injection or purchasing instructions.	Prednisone is classified here as Systemic glucocorticoid prodrug medicine. Extensive prescription evidence applies to disease-specific regimens and monitoring, not general recovery or performance use. FDA-authorised prescription products exist; WADA prohibits systemic glucocorticoids in competition by specified routes and requires current rule checking. A catalogue name does not establish identity, formulation, quality or authorisation, and this page provides no dosage, mixing, injection or purchasing instructions.
Unknowns	Insufficient data in the current dataset	Insufficient data in the current dataset	Insufficient data in the current dataset
Limitations	Levothyroxine / T4 molecule or active moiety ≠ ester/salt ≠ formulation ≠ brand ≠ supplier product; biological plausibility or historical use ≠ current approval ≠ safe performance use	Liothyronine sodium / T3 molecule or active moiety ≠ ester/salt ≠ formulation ≠ brand ≠ supplier product; biological plausibility or historical use ≠ current approval ≠ safe performance use	Prednisone molecule or active moiety ≠ ester/salt ≠ formulation ≠ brand ≠ supplier product; biological plausibility or historical use ≠ current approval ≠ safe performance use
Sources	DailyMed · Levothyroxine / T4 human drug-label inventory FDA · Why unapproved drugs require product-specific review WADA · 2026 Prohibited List	DailyMed · Liothyronine sodium / T3 human drug-label inventory FDA · Why unapproved drugs require product-specific review WADA · 2026 Prohibited List	DailyMed · Prednisone human drug-label inventory FDA · Why unapproved drugs require product-specific review WADA · 2026 Prohibited List
Read more	Read English overview Complete evidence profile (Thai)	Read English overview Complete evidence profile (Thai)	Read English overview Complete evidence profile (Thai)

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Missing fields mean information is unavailable in the current structured dataset, not that a molecule has no risks or uncertainties. English translations retain the original evidence boundaries. Where translation is not yet verified, the original Thai excerpts remain available under an explicit label. Sources retain their original language.

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